Phase II: PRECISE-SG100K

Collecting, Characterising, and Cataloguing Biological and Molecular Data of 100,000 Singaporeans

Overview of PRECISE-SG100K Resource

The PRECISE-SG100K resource is a unique multi-ancestry Asian population cohort dataset of ~100,000 Singaporean residents drawn from four major prospective population health studies in Singapore: ^[1] HELIOS-NTU, SPHS-NUS, SERI-SEED and NHCS-SingHeart. This extensive resource includes:

Research Phenotype Data

1. Questionnaire Data

• Detailed health and lifestyle information, including medical history, medications, behavioural risk factors, mental health, and socio-economic status

• Singapore-specific food frequency data, enabling detailed analysis of dietary patterns and nutrient intake

• Cognitive function assessments using validated memory and thinking tests

2. Physical Measurements

• Comprehensive anthropometric measurements

• Digital blood pressure readings

• 12-lead ECG for cardiac assessment

• Spirometry results

• 7-day physical activity data using Axivity tri-axial accelerometry

3. Advanced Imaging

• DXA scans for bone density and body composition

• Carotid ultrasound for cardiovascular assessment

• Detailed eye examinations including retinal photography, OCT, tonometry, and refraction

• Coronary artery calcification data (representative subset of 2,000 participants)

Molecular Data

Whole genome sequencing data (short read 30X coverage sequencing) generated with the Genome Institute of Singapore (A*STAR) under Phase II of Singapore’s National Precision Medicine Programme.

*Please note: Data availability may be phased, with some datasets becoming accessible at later stages.

^[1] Health for Life in Singapore Study (HELIOS), National Technological University (NTU); Singapore Population Health Studies (SPHS), National University of Singapore (NUS); Singapore Eye Research Institute (SERI) – Singapore Epidemiology of Eye Diseases (SEED); National Heart Centre Singapore (NHCS) – SingHeart

The PRECISE-SG100K Scientific Committee

The PRECISE-SG100K Scientific Committee comprises distinguished experts from across Singapore's research ecosystem who provide strategic oversight and scientific guidance for research utilising the PRECISE-SG100K resource. This expert panel plays a pivotal role in promoting scientific excellence while maximising the impact and public benefit of precision medicine research in Singapore.

The Committee's Key Responsibilities Encompass:

• Guiding the development and progression of scientific research based on the PRECISE-SG100K resource

• Providing oversight for approved Flagship and Driver projects that address critical knowledge gaps in precision medicine

• Evaluating new research proposals through the Call for Proposals process

• Reviewing project progress and encouraging cross-institutional collaboration

• Approving key scientific publications to maintain rigorous standards

Working closely with the PRECISE-SG100K Data Access Committee, the Scientific Committee serves as a vital resource in evaluating applications for data access, ensuring that research proposals demonstrate scientific merit, align with national priorities, and contribute meaningfully to advancing precision medicine. Through their expertise and guidance, the Committee helps foster a collaborative research environment that positions Singapore at the forefront of precision medicine research in Asia.