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Precision Health Research, Singapore (PRECISE)

About PRECISE-SG100K

Discover the breadth of data available in the PRECISE-SG100K resource, covering the cohort overview, research phenotype data, and molecular data collected from ~100,000 Singaporeans.

Last updated on 16 October 2026

Cohort Overview

Collecting, Characterising, and Cataloguing Biological and Molecular Data of 100,000 Singaporeans

The PRECISE-SG100K resource is a unique multi-ancestry Asian population cohort dataset of ~100,000 Singaporean residents drawn from four major prospective population health studies in Singapore: HELIOS-NTU, SPHS-NUS, SERI-SEED and NHCS-SingHeart. [1]

This extensive resource includes:

Research Phenotype Data

1. Questionnaire Data

  • Detailed health and lifestyle information, including medical history, medications, behavioural risk factors, mental health, and socio-economic status

  • Singapore-specific food frequency data, enabling detailed analysis of dietary patterns and nutrient intake

  • Cognitive function assessments using validated memory and thinking tests

2. Physical Measurements

  • Comprehensive anthropometric measurements

  • Digital blood pressure readings

  • 12-lead ECG for cardiac assessment

  • Spirometry results

  • 7-day physical activity data using Axivity tri-axial accelerometry

3. Advanced Imaging

  • DXA scans for bone density and body composition

  • Carotid ultrasound for cardiovascular assessment

  • Detailed eye examinations including retinal photography, OCT, tonometry, and refraction

  • Coronary artery calcification data (representative subset of 2,000 participants)

Molecular Data

Whole genome sequencing data (short read 30X coverage sequencing) generated with the Genome Institute of Singapore (A*STAR) under Phase II of Singapore’s National Precision Medicine Programme.

* NOTE:
Data availability may be phased, with some datasets becoming accessible at later stages.

[1] Health for Life in Singapore Study (HELIOS), National Technological University (NTU); Singapore Population Health Studies (SPHS), National University of Singapore (NUS); Singapore Eye Research Institute (SERI) – Singapore Epidemiology of Eye Diseases (SEED); National Heart Centre Singapore (NHCS) – SingHeart

PRECISE-SG100K Cohort Overview and Data Types

Resources