About PRECISE-SG100K

Cohort Overview

Collecting, Characterising, and Cataloguing Biological and Molecular Data of 100,000 Singaporeans

The PRECISE-SG100K resource is a unique multi-ancestry Asian population cohort dataset of ~100,000 Singaporean residents drawn from four major prospective population health studies in Singapore: HELIOS-NTU, SPHS-NUS, SERI-SEED and NHCS-SingHeart. ^[1]

This extensive resource includes:

Research Phenotype Data

1. Questionnaire Data

• Detailed health and lifestyle information, including medical history, medications, behavioural risk factors, mental health, and socio-economic status

• Singapore-specific food frequency data, enabling detailed analysis of dietary patterns and nutrient intake

• Cognitive function assessments using validated memory and thinking tests

2. Physical Measurements

• Comprehensive anthropometric measurements

• Digital blood pressure readings

• 12-lead ECG for cardiac assessment

• Spirometry results

• 7-day physical activity data using Axivity tri-axial accelerometry

3. Advanced Imaging

• DXA scans for bone density and body composition

• Carotid ultrasound for cardiovascular assessment

• Detailed eye examinations including retinal photography, OCT, tonometry, and refraction

• Coronary artery calcification data (representative subset of 2,000 participants)

Molecular Data

Whole genome sequencing data (short read 30X coverage sequencing) generated with the Genome Institute of Singapore (A*STAR) under Phase II of Singapore’s National Precision Medicine Programme.

^[1] Health for Life in Singapore Study (HELIOS), National Technological University (NTU); Singapore Population Health Studies (SPHS), National University of Singapore (NUS); Singapore Eye Research Institute (SERI) – Singapore Epidemiology of Eye Diseases (SEED); National Heart Centre Singapore (NHCS) – SingHeart